Axon-attacking antibodies
نویسندگان
چکیده
منابع مشابه
Axon-attacking antibodies
Axons have an Achilles’ heel that antibodies can attack to cause multiple sclerosis (MS), Mathey et al. show on page 2363. MS is triggered when T cells breach the blood–brain barrier and produce inflammatory cytokines that activate myelin-scavenging macrophages, causing damage to the myelin sheath. Myelin-specific antibodies that enter the brain in the T cells’ wake enhance the destruction of t...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2007
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20410iti2